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A domesticated skunk.

A pet skunk is a skunk kept by humans for companionship and enjoyment. Although capable of living indoors with humans similarly to dogs or cats, pet skunks are relatively rare, partly due to restrictive laws and the complexity of their care. Pet skunks are mainly kept in the United States, Canada, Germany, the Netherlands, and Italy.

In the United States, pet skunks can be purchased from licensed animal shelters, non-profit skunk educational organizations such as the American Domestic Skunk Association, Inc., or breeders with a permit from the U.S. Department of Agriculture's Animal and Plant Health Inspection Service. Baby skunk availability peaks during springtime, immediately following the skunk mating season. Some large fur farms sell surplus skunks to pet stores.

Skunks are probably best known for their ability to spray foul-smelling fluid as a defense against predators. Most wild skunks spray only when injured or attacked, as a defense mechanism. The mercaptan-emitting scent glands (commonly referred to as "the stinker") are usually removed in pet skunks at about four weeks of age.